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  Indian J Med Microbiol
 

Figure 3: The working flowchart for diagnostic approach of CD-LN features. The major steps toward diagnosis include the number of LN stations, associated features of POEMS, and the concomitant HHV-8 infection. The diagnostic criteria for iMCD [12] and TAFRO syndrome [18] are provided. A differential diagnosis is listed on the right side. CD: Castleman disease, CMV: Cytomegalovirus, EBV: Epstein–Barr virus, HIV: Human immunodeficiency virus, HSV: Herpes simplex virus, iMCD: Idiopathic multicentric Castleman disease, POEMS syndrome: Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes syndrome, TAFRO syndrome: Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly syndrome, TB, Mycobacterium tuberculosis, UCD: Unicentric Castleman disease

Figure 3: The working flowchart for diagnostic approach of CD-LN features. The major steps toward diagnosis include the number of LN stations, associated features of POEMS, and the concomitant HHV-8 infection. The diagnostic criteria for iMCD <sup>[12]</sup> and TAFRO syndrome <sup>[18]</sup> are provided. A differential diagnosis is listed on the right side. CD: Castleman disease, CMV: <i>Cytomegalovirus</i>, EBV: Epstein–Barr virus, HIV: Human immunodeficiency virus, HSV: Herpes simplex virus, iMCD: Idiopathic multicentric Castleman disease, POEMS syndrome: Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes syndrome, TAFRO syndrome: Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly syndrome, TB, Mycobacterium tuberculosis, UCD: Unicentric Castleman disease