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  Indian J Med Microbiol
 

Figure 1: Histologic features in lymph node of Castleman disease. (a) Germinal center hyalinization and onion skin appearance of the mantle zone (white arrow). There is prominent vascular proliferation, the so-called “lollipop” feature (black arrow). The interfollicular area contains abundant plasma cells (hematoxylin and eosin stain). (b) The lymph node is positive for latency-associated nuclear antigen-1 (LANA-1) stain, indicating that plasma cells were infected by HHV-8 virus (×100)

Figure 1: Histologic features in lymph node of Castleman disease. (a) Germinal center hyalinization and onion skin appearance of the mantle zone (white arrow). There is prominent vascular proliferation, the so-called “lollipop” feature (black arrow). The interfollicular area contains abundant plasma cells (hematoxylin and eosin stain). (b) The lymph node is positive for latency-associated nuclear antigen-1 (LANA-1) stain, indicating that plasma cells were infected by HHV-8 virus (×100)