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Figure 2: Expression of CX3CR1/CX3CL1 varies at different stages of Alzheimer's disease. During the early stage, CX3CR1/CX3CL1 signaling is low, and moderate microglial activation protects the neurons. At a later stage, when the disease progresses because of neuronal loss, CX3CR1/CX3CL1 signaling diminishes, resulting in microglial over activat |
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