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  Indian J Med Microbiol
 

Figure 1: Modulation of microglia by CX3CL1/CX3CR1 and P2X7R signaling. A schematic of CX3CL1/CX3CR1 and P2X7R signaling under normal and pathological conditions. The CX3CL1/CX3CR1 pathway can stop the activation of mic, whereas ATP binding with P2X7R can induce microglial activation. Alzheimer's disease affects the regulation of these two signaling molecules, leading to microglial overactivation, thus resulting in pathological changes

Figure 1: Modulation of microglia by CX3CL1/CX3CR1 and P2X<sub>7</sub>R signaling. A schematic of CX3CL1/CX3CR1 and P2X<sub>7</sub>R signaling under normal and pathological conditions. The CX3CL1/CX3CR1 pathway can stop the activation of mic, whereas ATP binding with P2X<sub>7</sub>R can induce microglial activation. Alzheimer's disease affects the regulation of these two signaling molecules, leading to microglial overactivation, thus resulting in pathological changes