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  Indian J Med Microbiol
 

Figure 5: Safrole was demonstrated to induce phosphorylation of mitogen-activated protein kinase family, including p38 mitogen-activated protein kinase (a), extracellular signal-regulated kinase (b), and c-Jun N-terminal kinase (c) in RAW264.7 macrophages. RAW264.7 cells incubated with safrole at 0, 1, 10, 100, or 300 μM for 30 min. RAW264.7 cells treated with safrole at 0 μM served as the control group. Phosphorylation of p38 mitogen-activated protein kinase phosphorylation, extracellular signal-regulated kinase, and c-Jun N-terminal kinase was measured by Western blot assay. Results are expressed as means ± standard deviation (n = 3). *P < 0.05 considers significant as compared with control group

Figure 5: Safrole was demonstrated to induce phosphorylation of mitogen-activated protein kinase family, including p38 mitogen-activated protein kinase (a), extracellular signal-regulated kinase (b), and c-Jun N-terminal kinase (c) in RAW264.7 macrophages. RAW264.7 cells incubated with safrole at 0, 1, 10, 100, or 300 μM for 30 min. RAW264.7 cells treated with safrole at 0 μM served as the control group. Phosphorylation of p38 mitogen-activated protein kinase phosphorylation, extracellular signal-regulated kinase, and c-Jun N-terminal kinase was measured by Western blot assay. Results are expressed as means ± standard deviation (<i>n</i> = 3). *<i>P</i> < 0.05 considers significant as compared with control group