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  Indian J Med Microbiol
 

Figure 7: Schematic of adaptive immunoregulation of LUT and chlorogenic acid in LPS-induced IL-10 expression. CGA enhanced LPS-induced expression of IL-10 and IL-6 and increased the expression of NF-κB, Sp1, C/EBPβ, and δ. The effect of CGA was interfered with LUT by suppressing the phosphorylation of IκB and p38 and downregulated NF-κB activity. In the event, IL-6 was suppressed and IL-10 was not influenced. LPS: Lipopolysaccharide, CGA: Chlorogenic acid, LUT: Luteolin, NF-κB: Nuclear factor-κB, IL-10: Interleukin-10

Figure 7: Schematic of adaptive immunoregulation of LUT and chlorogenic acid in LPS-induced IL-10 expression. CGA enhanced LPS-induced expression of IL-10 and IL-6 and increased the expression of NF-κB, Sp1, C/EBPβ, and δ. The effect of CGA was interfered with LUT by suppressing the phosphorylation of IκB and p38 and downregulated NF-κB activity. In the event, IL-6 was suppressed and IL-10 was not influenced. LPS: Lipopolysaccharide, CGA: Chlorogenic acid, LUT: Luteolin, NF-κB: Nuclear factor-κB, IL-10: Interleukin-10