Tzu Chi Medical Journal

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 30  |  Issue : 2  |  Page : 85--89

High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients


Yu-Hsien Lai1, Chih-Hsien Wang1, Jen-Pi Tsai2, Jia-Sian Hou3, Chung-Jen Lee4, Bang-Gee Hsu5 
1 Department of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
2 Department of Nephrology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi; School of Medicine, Tzu Chi University, Hualien, Taiwan
3 Department of Nursing, Buddhist Tzu Chi General Hospital; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
4 Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan
5 Department of Nephrology, Buddhist Tzu Chi General Hospital; School of Medicine, Tzu Chi University, Hualien, Taiwan

Correspondence Address:
Dr. Bang-Gee Hsu
Department of Nephrology, Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien
Taiwan

Objective: Peripheral artery disease (PAD) is associated with systemic atherosclerosis and indicates an increased risk of mortality in peritoneal dialysis (PD) patients. A high leptin level accelerates atherosclerosis in apoE-deficient mice. The purpose of this study was to examine the association of serum leptin level and PAD in adult PD patients. Materials and Methods: The clinical characteristics of sixty PD patients recruited from June 2015 to October 2016 were obtained. Serum leptin concentrations were determined. Ankle–brachial index (ABI) values were measured and those with a left or right ABI <0.9 were defined as the low ABI group. Results: Twenty of these 60 PD patients (33.3%) had diabetes mellitus and 32 patients (53.3%) had hypertension. Thirteen PD patients (21.7%) were in the low ABI group. Higher serum leptin (P = 0.002) and C-reactive protein (CRP, P < 0.001) levels were found in the low ABI group compared with those in the normal ABI group. More number of patients with diabetes (P = 0.015) and current smokers (P = 0.037) were noted in the low ABI group than in the normal ABI group. After adjustment for factors that were significantly associated with PAD in multivariate logistic regression analysis, each increase of 1 ng/mL in the serum leptin level (odds ratio [OR], 1.062; 95% confidence interval [CI], 1.014–1.114; P = 0.012) and each increase of 0.1 mg/dL in the serum CRP level (OR, 1.107; 95% CI, 1.011–1.211; P = 0.028) were found to be independent predictors of PAD in PD patients. Conclusion: Higher serum leptin and CRP levels correlated positively with the diagnosis of PAD in PD patients.


How to cite this article:
Lai YH, Wang CH, Tsai JP, Hou JS, Lee CJ, Hsu BG. High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients.Tzu Chi Med J 2018;30:85-89


How to cite this URL:
Lai YH, Wang CH, Tsai JP, Hou JS, Lee CJ, Hsu BG. High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients. Tzu Chi Med J [serial online] 2018 [cited 2021 May 7 ];30:85-89
Available from: https://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=2;spage=85;epage=89;aulast=Lai;type=0