Tzu Chi Medical Journal

: 2017  |  Volume : 29  |  Issue : 4  |  Page : 237-

Leptin as an independent marker of metabolic syndrome

Beuy Joob1, Viroj Wiwanitkit2,  
1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Tropical Medicine, Hainan Medical University, Hainan Sheng, China

Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok

How to cite this article:
Joob B, Wiwanitkit V. Leptin as an independent marker of metabolic syndrome.Tzu Chi Med J 2017;29:237-237

How to cite this URL:
Joob B, Wiwanitkit V. Leptin as an independent marker of metabolic syndrome. Tzu Chi Med J [serial online] 2017 [cited 2021 May 7 ];29:237-237
Available from:

Full Text

Dear Editor,

The publication on “Leptin as an independent marker of metabolic syndrome” by Tseng et al. is very interesting [1]. Tseng et al. concluded that “Serum leptin is positively correlated with MetS. It serves as an independent marker of MetS in elderly patients with T2DM [1].” In fact, the usefulness of serum leptin is widely mentioned. Nevertheless, there are many possible confounding factors that might disturb the determination. First, exercise can result in lowering leptin level [2]. Second, in the case with underlying liver problem and abnormal elevated bilirubin level (such as in cases with chronic hepatitis), the interference on leptin level measurement is possible [3]. Hence, the patients with underlying hepatitis should be excluded from the study. These factors have to be concerned in the study by Tseng et al. [1].

Financial Support and Sponsorship


Conflicts of interest

There are no conflicts of interest.


1Tseng PW, Wu DA, Hou JS, Hsu BG. Leptin is an independent marker of metabolic syndrome in elderly adults with type 2 diabetes. Tzu Chi Med J 2017;29:109-14.
2Pop D, Dadârlat A, Bodizs G, Stanca L, Zdrenghea D. The response of circulating leptin levels to exercise stress testing in subjects diagnosed with metabolic syndrome. ISRN Endocrinol 2014;2014:689260.
3Theriault A, Agdinaoay T, Ladao NB, Chang H, Grandinetti A. Clinical evaluation of a new non-isotopic leptin immunoassay. Clin Lab Sci 2001;14:6-8.