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Interleukin-10: A double-edged sword in breast cancer


1 Department of General Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
2 Institute of Medical Sciences; Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien, Taiwan
3 Department of Biochemistry, School of Medicine; Department of Life Sciences, College of Medicine, Tzu Chi University, Hualien, Taiwan
4 Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien, Taiwan

Correspondence Address:
Hao-Jen Hsu,
Department of Biochemistry, School of Medicine, Tzu Chi University, 701, Section 3, Zhongyang Road, Hualien
Taiwan
Shinn-Jong Jiang,
Department of Biochemistry, School of Medicine, Tzu Chi University, 701, Section 3, Zhongyang Road, Hualien
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tcmj.tcmj_162_20

Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgroups has different treatment strategies. However, the presence of new metastatic lesions and patient deterioration suggest resistance to a given treatment. Various lines of evidence had shown that cytokines are one of the important mediators of tumor growth, invasion, metastasis, and treatment resistance. Interleukin-10 (IL-10) is an immunoregulatory cytokine, and acts as a poor prognostic marker in many cancers. The anti-inflammatory IL-10 blocks certain effects of inflammatory cytokines. It also antagonizes the co-stimulatory molecules on the antigen-presenting cells. Here, we review the current knowledge on the function and molecular mechanism of IL-10, and recent findings on how IL-10 contributes to the progression of BC.


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    -  Lam HY
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