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  Indian J Med Microbiol
 

Figure 2: Effects of age on norepinephrine-induced relaxation. Norepinephrine (NE, 0.001–10 μM)-induced relaxation in with (a) and without (b) mucosa bladder strips of aging mice (12 and 24 months, n = 6), in the presence of active muscle tone induced by acetylcholine (10 μM). The NE-induced relaxation was significantly greater in 12-month than that in 24-month mice urinary bladder (n = 6, P < 0.05). This NE (0.001–10 μM)-induced relaxation was significantly inhibited by silodosin (10 μM, n = 5, c), and lidocaine (0.1 mM, n = 5, P < 0.05, c) in 12-month mice with urothelium. Values are mean ± standard error mean. n = number of experiments. W: wash. Asterisk indicates a significant difference in Bonferroni posttests following ANOVA (*P < 0.05)

Figure 2: Effects of age on norepinephrine-induced relaxation. Norepinephrine (NE, 0.001–10 μM)-induced relaxation in with (a) and without (b) mucosa bladder strips of aging mice (12 and 24 months, <i>n</i> = 6), in the presence of active muscle tone induced by acetylcholine (10 μM). The NE-induced relaxation was significantly greater in 12-month than that in 24-month mice urinary bladder (<i>n</i> = 6, <i>P</i> < 0.05). This NE (0.001–10 μM)-induced relaxation was significantly inhibited by silodosin (10 μM, <i>n</i> = 5, c), and lidocaine (0.1 mM, <i>n</i> = 5, <i>P</i> < 0.05, c) in 12-month mice with urothelium. Values are mean ± standard error mean. <i>n</i> = number of experiments. W: wash. Asterisk indicates a significant difference in Bonferroni posttests following ANOVA (*<i>P</i> < 0.05)