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  Indian J Med Microbiol
 

Figure 1: Hic-5-mediated signaling pathways for tumor progression. Hic-5 can mediate a lot of signaling pathways including the positive feedback Traf4/ Pyk2-NADPH oxidase-ROS-JNK signal cascade, regulating the expression of epithelial–mesenchymal transition-related genes (left panel). Hydrogen peroxide-inducible clone-5 can also trigger MEK-ERK, Rac1-p38, or RhoA/ ROCK-Src pathway for cell migration and invasion (middle panel) and upregulating survivin for anti-apoptosis (right panel)

Figure 1: Hic-5-mediated signaling pathways for tumor progression. Hic-5 can mediate a lot of signaling pathways including the positive feedback Traf4/ Pyk2-NADPH oxidase-ROS-JNK signal cascade, regulating the expression of epithelial–mesenchymal transition-related genes (left panel). Hydrogen peroxide-inducible clone-5 can also trigger MEK-ERK, Rac1-p38, or RhoA/ ROCK-Src pathway for cell migration and invasion (middle panel) and upregulating survivin for anti-apoptosis (right panel)