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  Indian J Med Microbiol
 

Figure 2: Effects of naringenin on the pain threshold determined by a hot-plate test. Mice were placed on a hot plate at 55 ± 1°C. The latency was defined as the time to the first sign of paw licking or jumping response. Control, corn oil-treated vehicle group; Nar 50, mice treated with naringenin 50 mg/kg; Nar 100, treated with naringenin 100 mg/kg; Nar 200, treated with naringenin 200 mg/kg; Codeine, mice given 10 mg/kg codeine used as positive controls. Data are expressed as the mean ± standard deviation of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 (two-way ANOVA) compared with the vehicle control group

Figure 2: Effects of naringenin on the pain threshold determined by a hot-plate test. Mice were placed on a hot plate at 55 ± 1°C. The latency was defined as the time to the first sign of paw licking or jumping response. Control, corn oil-treated vehicle group; Nar 50, mice treated with naringenin 50 mg/kg; Nar 100, treated with naringenin 100 mg/kg; Nar 200, treated with naringenin 200 mg/kg; Codeine, mice given 10 mg/kg codeine used as positive controls. Data are expressed as the mean ± standard deviation of three independent experiments. *<i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001 (two-way ANOVA) compared with the vehicle control group