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  Indian J Med Microbiol
 

Figure 1: (a) The DNA sequence of DRB1*15:140 is identical to DRB1*15:02:01:01 in exon 1 and exon 2 (only exon 1 is shown here), except for residue 91 where a G in DRB1*15:02:01:01 is replaced by an A (shaded) (at codon 2; GAC->AAC; underlined) in DRB1*15:140. (b) The nucleotide substitution introduces a one amino acid substitution at residue 2 where an aspartic acid (D) of DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140 (shaded). Since nucleotides before codon 1 (GGG) at the 5' end of the sequence DRB1*15:140 are a noncoding sequence, the amino acid encoded by codon 2 (AAC) is the second amino acid residue of the DRB1*15:140 protein molecule. Dashes indicate nucleotide or amino acid identity with DRB1*15:02:01:01

Figure 1: (a) The DNA sequence of DRB1*15:140 is identical to DRB1*15:02:01:01 in exon 1 and exon 2 (only exon 1 is shown here), except for residue 91 where a G in DRB1*15:02:01:01 is replaced by an A (shaded) (at codon 2; GAC->AAC; underlined) in DRB1*15:140. (b) The nucleotide substitution introduces a one amino acid substitution at residue 2 where an aspartic acid (D) of DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140 (shaded). Since nucleotides before codon 1 (GGG) at the 5' end of the sequence DRB1*15:140 are a noncoding sequence, the amino acid encoded by codon 2 (AAC) is the second amino acid residue of the DRB1*15:140 protein molecule. Dashes indicate nucleotide or amino acid identity with DRB1*15:02:01:01