Tzu Chi Medical Journal

LETTER TO THE EDITOR
Year
: 2019  |  Volume : 31  |  Issue : 4  |  Page : 295-

Reply from authors for Serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes


Chia-Wen Lu1, Chung-Jen Lee2, Jia-Sian Hou3, Du-An Wu4, Bang-Gee Hsu5,  
1 Department of Nursing, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
2 Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan
3 Department of Nursing, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
4 Department of Metabolism and Endocrinology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; School of Medicine, Tzu Chi University, Hualien, Taiwan
5 Institute of Medical Sciences, Tzu Chi University; School of Medicine, Tzu Chi University; Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

Correspondence Address:
Dr. Bang-Gee Hsu
Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 707, Section 3, Chung-Yang Road, Hualien
Taiwan




How to cite this article:
Lu CW, Lee CJ, Hou JS, Wu DA, Hsu BG. Reply from authors for Serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes.Tzu Chi Med J 2019;31:295-295


How to cite this URL:
Lu CW, Lee CJ, Hou JS, Wu DA, Hsu BG. Reply from authors for Serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes. Tzu Chi Med J [serial online] 2019 [cited 2020 Sep 22 ];31:295-295
Available from: http://www.tcmjmed.com/text.asp?2019/31/4/295/266926


Full Text

Dear Editor,

We thankYasriand Wiwanitkit for their comments on our work [1]. In their response, they showed other factors that might alter the serum leptin level and this might be a limitation in using serum leptin as a clinical parameter in metabolic syndrome such in liver disease [1]. Many factors may affect serum leptin levels such as physical activity, statin used and pharmacological intervention toward against renin-angiotensin system [2]. In our study did not show significantly different of leptin levels between those treated or not with statins, fibrates, or antidiabetic drugs on peripheral arterial stiffness in patients with type 2 diabetes mellitus [3]. Leptin is known to contribute to fibrogenesis in chronic liver diseases [4]. However, studies on leptin levels and liver disease are controversial [4]. Further studies are needed to confirm the liver disease on serum leptin levels in the future.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Yasri S, Wiwanitkit V. Serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes. Tzu Chi Med J 2019;31:294.
2Tsai JP. The association of serum leptin levels with metabolic diseases. Tzu Chi Med J 2017;29:192-6.
3Lu CW, Lee CJ, Hou JS, Wu DA, Hsu BG. Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes. Tzu Chi Med J 2018;30:10-4.
4Buechler C, Haberl EM, Rein-Fischboeck L, Aslanidis C. Adipokines in liver cirrhosis. Int J Mol Sci 2017;18:E1392.