|Ahead of print publication
The role of tea and coffee in the development of gastroesophageal reflux disease
Tao-Yang Wei1, Pang-Hsin Hsueh2, Shu-Hui Wen3, Chien-Lin Chen4, Chia-Chi Wang1
1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei; School of Medicine, Tzu Chi University, Hualien, Taiwan
2 School of Medicine, Tzu Chi University, Hualien; Department of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan
3 Department of Public Health, College of Medicine, Tzu Chi University, Hualien, Taiwan
4 School of Medicine, Tzu Chi University; Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
|Date of Submission||21-Feb-2018|
|Date of Decision||22-Mar-2018|
|Date of Acceptance||22-Jun-2018|
|Date of Web Publication||14-Aug-2018|
Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 289, Jianguo Road, New Taipei
Source of Support: None, Conflict of Interest: None
Objective: The incidence of gastroesophageal reflux disease (GERD) is increasing, and the disease has a close association with dietary habits. This study aims to investigate the role of tea and coffee drinking in the development of GERD. Materials and Methods: This study prospectively enrolled individuals who underwent an upper gastrointestinal endoscopy during a health checkup. Each participant completed the reflux disease questionnaire (RDQ). Coffee or tea drinking was defined as drinking the beverage at least 4 days/week for 3 months. Heavy coffee or tea consumption was defined as drinking at least two cups every day. Results: A total of 1837 participants (970 men; age 51.57 ± 10.21 years), who had data on clinical characteristics and consumption of coffee and tea with or without additives such as milk or sugar were included for final analysis. Among them, 467 (25.4%) were diagnosed as having symptomatic GERD based on the RDQ score, and 427 (23.2%) had erosive esophagitis (EE) on endoscopy. Drinking coffee or tea was not associated with reflux symptoms or EE in univariate and multivariate analyses. In contrast, drinking coffee with milk was associated with reflux symptoms and drinking “tea and coffee” was associated with EE in univariate analysis. However, these associations became insignificant after multivariate analysis. Conclusion: Drinking coffee or tea and adding milk or sugar was not associated with reflux symptoms or EE.
Keywords: Coffee, Gastroesophageal reflux disease, Helicobacter pylori, Hiatus hernia, Tea
|How to cite this URL:|
Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The role of tea and coffee in the development of gastroesophageal reflux disease. Tzu Chi Med J [Epub ahead of print] [cited 2018 Dec 14]. Available from: http://www.tcmjmed.com/preprintarticle.asp?id=239038
Tao-Yang Wei and Pang-Hsin Hsueh contributed equally to this work.
| Introduction|| |
Gastroesophageal reflux disease (GERD) is a common disorder and requires substantial medical resources worldwide . The incidence is increasing in most western and some Asian countries . The prevalence is as high as 25% in Taiwan . It can affect the quality of life, with complications such as esophagitis, ulcers, bleeding, strictures, Barrett's esophagus, and adenocarcinoma ,,. The diagnosis depends on typical symptoms such as heartburn and acid regurgitation. However, not all symptomatic patients have esophageal mucosal injury on endoscopy . The pathogenesis may be multifactorial affecting mainly the lower esophageal sphincter . The use of a proton pump inhibitor is the gold standard treatment for relief of reflux symptoms and healing of the mucosal injury. However, the therapeutic response is still unsatisfactory especially for those patients with nonacidic reflux or esophageal hypersensitivity. Research on new compounds and identifying the risk factors of GERD would be helpful in the treatment of refractory GERD ,,.
Several risk factors such as obesity and hiatus hernia have been associated with the development of GERD ,,. However, the role of popular beverages in the development of GERD is still controversial. Coffee and tea are the most popular beverages in the world. People initially drink coffee or tea because of the taste and fragrance. The health benefits of these beverages have been explored in recent years. Coffee had been reported to reduce the risk of metabolic syndrome (MS), Alzheimer's disease, and colon cancer ,,,. Health benefits have also been found from green and black tea . Green tea can improve MS and obesity . However, studies assessing the association of coffee and tea with GERD are scarce and findings have been inconsistent . In addition, whether additives such as milk or sugar have any impact on GERD has never been discussed. Thus, we performed a cross-sectional study using a large-scale health checkup cohort to clarify whether the consumption of tea and coffee and additives affects the development of GERD.
| Materials and Methods|| |
A total of 2604 participants who underwent an upper gastrointestinal endoscopy during a health checkup at the Health Examination Center of Taipei Tzu Chi Hospital from March 2012 to August 2013 were enrolled prospectively. Participants with missing clinical or biochemical data (n = 445) or incomplete answers about their coffee or tea consumption (n = 322) were excluded from the study. Each participant completed the reflux disease questionnaire (RDQ). The RDQ was previously validated as an instrument for the diagnosis of symptomatic GERD ,,. The Clinical and biochemical data and information on coffee and tea consumption were collected. Coffee or tea drinking was defined as drinking the beverage at least 4 days/week for 3 months. Heavy coffee or tea consumption was defined as drinking at least two cups every day. Sugar or milk use was defined t as use of the additive more than 80% of the time. The Ethics Committees of Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation approved this study and each participant provided informed consent (01-XD08-013).
Reflux disease questionnaire and endoscopic findings
In our study, a face-to-face interview was performed during the health checkup, and the questionnaire was completed at the same interview. The RDQ was designed to assess the symptoms of heartburn, acid regurgitation, and dyspepsia. It includes 12 questions on the frequency and severity of burning and pain behind the breastbone, an acid taste in the mouth, movement of materials upward from stomach, and burning and pain in the upper stomach ,. Responses range from 0 to 5 points. After excluding the dyspepsia scale, scores for the RDQ range from 0 to 40. Symptomatic GERD is defined as mild reflux symptoms at least two times/week or moderate reflux symptoms at least once per week. An esophagogastroduodenoscopy was performed on each participant under sedation. Experienced endoscopists were performed all procedures and were blinded to the results of the questionnaire. Erosive esophagitis (EE) on endoscopy was graded from A to D according to the Los Angeles classification . Another experienced endoscopist reviewed the endoscopic imaging to confirm a diagnosis of EE. If there was disagreement on the diagnosis, the final diagnosis was made by consensus of three experienced endoscopists.
Personal and medical information
Personal data, including age, gender, body mass index (BMI), and history of hyperlipidemia, diabetes mellitus, hypertension, smoking, alcohol drinking, and use of aspirin and a nonsteroidal anti-inflammatory drugs (NSAIDs), were collected. The definition of alcohol drinking in our study was drinking alcohol at least once per week. The use of aspirin and an NSAID was defined as having taken these drugs in the previous 3 months. An automatic analyzer measured serum fasting blood glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TGs) (Roche Analytics; Roche Professional Diagnostics, Penzberg, Germany). Helicobacter pylori infection was assessed by a rapid urease test during the esophagogastroduodenoscopy.
We used SAS Version 9.2 (SAS Institute, Cary, NC, USA) to perform all analyses. Continuous data were presented as mean with standard deviations while categorical data were presented as percentages. The Chi-square test and Student's t-test were applied to analyze continuous and categorical variables. The association of potential risk factors with symptomatic GERD or EE was determined using multivariate analysis. P < 0.05 was considered statistically significant.
| Results|| |
Personal and clinical data from the study samples
A total of 1837 participants were recruited for the final analysis. Of these, 1197 (65.2%) drank coffee, of which 185 (15.5%) participants were heavy coffee drinkers. In total, 538 (44.9%) subjects added milk to their coffee and 340 (28.4%) participants added sugar. A total of 1215 (66.1%) participants drank tea. Of these, 275 (22.6%) participants were defined as heavy tea drinkers. In total, 49 (4%) participants added sugar to their tea. H. pylori were positive in 493 (26.8%) participants. Altogether 467 (25.4%) participants were diagnosed with symptomatic GERD based on RDQ scores and 427 (23.2%) participants had EE on endoscopy. The relationship between reflux symptoms and EE is presented in [Table 1]. The percentage of consistence between reflux symptoms and EE EE was 65.6%. Personal and clinical data stratified by gender are shown in [Table 2]. In our study samples, men had higher percentages of heavy tea drinking, smoking, alcohol consumption, use of aspirin, hypertension, hyperlipidemia, H. pylori infection, hiatus hernia, and EE; however, a lower percentage of adding milk to coffee than women. Furthermore, men had higher BMIs, and glucose and TG levels, but lower HDL levels than women.
|Table 1: Relationship between reflux symptoms and erosive esophagitis in the study samples|
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|Table 2: Personal and clinical data of the study samples stratified by gender|
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Clinical characteristics of patients with gastroesophageal reflux disease and erosive esophagitis
There were significant differences regarding adding milk to coffee, serum TG level <150, serum LDL level <130, and the presence of H. pylori between those with and without symptomatic GERD. There were no significant differences in these groups for tea drinking, heavy tea drinking, adding sugar to tea, coffee drinking, heavy coffee drinking, adding sugar to coffee or drinking “tea and coffee.” There were significant differences regarding gender, BMI <25, drinking “tea and coffee,” smoking, hypertension, hyperlipidemia, TG levels <150, HDL levels >40, HbA1c levels <6, H. pylori, and hiatus hernia between subjects with and without EE. There were no significant differences in tea drinking, heavy tea drinking, adding sugar to tea, coffee drinking, heavy coffee drinking, adding milk to coffee, adding sugar to coffee, or drinking “tea and coffee” [Table 3].
|Table 3: Comparison of clinical characteristics of between patients with and without symptomatic gastroesophageal reflux disease or erosive esophagitis|
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Factors associated with reflux symptoms and erosive esophagitis on endoscopy using multivariate analysis
Multivariate analysis showed that LDL levels <130 and H. pylori infection were associated with reflux symptoms. Female gender, BMI <25, H. pylori infection, and hiatus hernia were associated with EE [Table 4].
|Table 4: Factors associated with gastroesophageal reflux disease and erosive esophagitis using multivariate analysis|
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Factors associated with erosive esophagitis using multivariate analysis stratified by gender
In our study samples, H. pylori infection and hiatus hernia were associated with EE in men. BMI <25, use of aspirin and hiatus hernia were associated with EE in women [Table 5].
|Table 5: Factors associated with erosive esophagitis on endoscopy using multivariate analysis stratified by gender|
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| Discussion|| |
In this study of 1837 participants from a health examination center, 467 (25.4%) were diagnosed as having symptomatic GERD according to RDQ scores and 427 (23.3%) had EE on endoscopy. Serum LDL levels and H. pylori infection were associated with reflux symptoms. Gender, BMI, H. pylori infection, and hiatus hernia were associated with EE on endoscopy. Our data concluded that drinking tea or coffee, and adding sugar or milk was not associated with reflux symptoms or EE.
GERD is diagnosed based on typical reflux symptoms including heartburn and/or regurgitation. The prevalence of GERD ranges from 2.5% to 33.1% in different areas of the world . A previous Taiwanese study reported that the prevalence of GERD was 25% in the community . The prevalence of GERD in our study was 25.4%, which is consistent with the previous report. In GERD patients, reflux symptoms had incomplete correspondence with EE on endoscopy. A population-based endoscopic study showed that two-thirds of the patients reporting reflux symptoms had no EE . Our previous study found that 14.5% of an asymptomatic population had EE . In our study samples, 71.95% of symptomatic GERD patients had nonerosive reflux disease and asymptomatic EE was found in 21.61% of the asymptomatic population. Our study similarly found incomplete correspondence between reflux symptoms and EE.
Food, beverages, and lifestyle have impacts on the development of GERD ,,,. Some previous studies reported a therapeutic effect of tea on H. pylori infection and peptic ulcer ,,. However, the role of tea, and coffee in the development of GERD is controversial , For example, a cross-sectional questionnaire study found 23.4% of 2853 participants had GERD. They found green tea drinkers had a higher risk of GERD with an odds ratio of 1.44 . However, a Chinese cohort study including 8831 retirees found no significant association between tea and reflux symptoms . In addition, an Indian study in a high altitude area revealed that salt tea had a protective effect against GERD . Another German study using an ambulatory pH meter showed that coffee, but not tea increased gastroesophageal reflux . Coffee was found to be a risk factor for GERD in some studies ,. In contrast, a case–control study including 3153 individuals showed a negative association between exposure to coffee and reflux symptoms . These inconsistent findings can be attributed to the different types of tea and coffee or the study population. In addition, additives, such as sugar or milk, were not discussed. Our survey revealed that tea, coffee, and added sugar or milk were not associated with reflux symptoms or EE.
H. pylori infection may protect against the development of GERD and its complications ,. Hiatus hernia is known to be a major risk factor in GERD development ,,,. Our study consistently found that the presence of hiatus hernia increased the risk of EE. In contrast, H. pylori infection seems to protect an individual from development of reflux symptoms and EE.
A Taiwanese study recruiting 1238 residents in a community revealed female gender, age of 40–49 years, and age of 50–59 years were independent risk factors for GERD . However, a systemic review did not find that female gender was a risk factor of GERD . Our results showed that women had a lower risk of EE, but not associated with reflux symptoms. Except for hiatus hernia, the risk factors for EE were different between t genders. H. pylori infection was associated with EE in men, but BMI and use of aspirin showed an association in women. The complex associations among gender, risk factors, and GERD need further investigation. Although older patients may underreport reflux symptoms, two European studies revealed a trend of older patients with a high prevalence of GERD ,. Our results showed that older age was not associated with reflux symptoms and EE.
Obesity, especially abdominal obesity may increase intragastric pressure, the gastroesophageal gradient, transient lower esophageal sphincter relaxation, and the duration of esophageal acid exposure and is currently considered a risk factor of for EE ,. Our study found that BMI was associated with EE in women.
Our study has several strengths. This is the first study to investigate tea, coffee, and additives such as sugar or milk in the development of GERD. In addition, since our study included the results of a questionnaire and endoscopic findings, the risk factors for reflux symptoms or EE could be identified. However, some limitations should be acknowledged. First, we only recorded the number of cups of coffee or tea per day, but not the strength of the coffee or tea. Furthermore, the types of tea such as green, black, or salt tea were not included in our questionnaire. Second, some medications are known to increase the risk of reflux symptoms and esophageal mucosal injury . Although the medication history, except for aspirin and NSAIDS, was not recorded in our study, this confounding effect might be minimal due to the relatively healthy condition of our study samples from a health examination center. Finally, since our study was cross-sectional, causal relationships cannot be determined.
In summary, drinking tea or coffee and adding sugar or milk was not associated with reflux symptoms or EE. Factors associated with reflux symptoms and EE included metabolic factors and hiatus hernia. In contrast, female gender and H. pylori infection seem to have a protective to against the development of EE.
Financial support and sponsorship
This work was financially supported by grants from Taipei Tzu Chi Hospital and Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-I101-02).
Conflicts of interest
There are no conflicts of interest.
| References|| |
Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: A systematic review. Gut 2005;54:710-7.
El-Serag HB. Time trends of gastroesophageal reflux disease: A systematic review. Clin Gastroenterol Hepatol 2007;5:17-26.
Hung LJ, Hsu PI, Yang CY, Wang EM, Lai KH. Prevalence of gastroesophageal reflux disease in a general population in Taiwan. J Gastroenterol Hepatol 2011;26:1164-8.
Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology 2004;126:660-4.
Lagergren J, Bergström R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999;340:825-31.
Falk GW. Reflux disease and barrett's esophagus. Endoscopy 1999;31:9-16.
Minatsuki C, Yamamichi N, Shimamoto T, Kakimoto H, Takahashi Y, Fujishiro M, et al. Background factors of reflux esophagitis and non-erosive reflux disease: A cross-sectional study of 10,837 subjects in Japan. PLoS One 2013;8:e69891.
Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux. Gut 1988;29:1020-8.
Boeckxstaens G, El-Serag HB, Smout AJ, Kahrilas PJ. Republished: Symptomatic reflux disease: The present, the past and the future. Postgrad Med J 2015;91:46-54.
Li CH, Hsieh TC, Hsiao TH, Wang PC, Tseng TC, Lin HH, et al. Different risk factors between reflux symptoms and mucosal injury in gastroesophageal reflux disease. Kaohsiung J Med Sci 2015;31:320-7.
Wang PC, Hsu CS, Tseng TC, Hsieh TC, Chen CH, Su WC, et al. Male sex, hiatus hernia, and Helicobacter pylori
infection associated with asymptomatic erosive esophagitis. J Gastroenterol Hepatol 2012;27:586-91.
Sarriá B, Martínez-López S, Sierra-Cinos JL, García-Diz L, Mateos R, Bravo-Clemente L, et al. Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr 2018;57:269-78.
Liu QP, Wu YF, Cheng HY, Xia T, Ding H, Wang H, et al. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition 2016;32:628-36.
Schmit SL, Rennert HS, Rennert G, Gruber SB. Coffee consumption and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2016;25:634-9.
Chang CH, Wu CP, Wang JD, Lee SW, Chang CS, Yeh HZ, et al. Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men. PLoS One 2017;12:e0173230.
Khan N, Mukhtar H. Tea and health: Studies in humans. Curr Pharm Des 2013;19:6141-7.
Sae-tan S, Grove KA, Lambert JD. Weight control and prevention of metabolic syndrome by green tea. Pharmacol Res 2011;64:146-54.
Gudjonsson H, McAuliffe TL, Kaye MD. The effect of coffee and tea upon lower esophageal sphincteric function. Laeknabladid 1995;81:484-8.
Hsu CS, Wang CC, Wang PC, Lin HH, Tseng TC, Chen CH, et al. Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection. Hepatol Int 2010;4:585-93.
Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, et al. Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 2001;96:52-7.
Cao Y, Yan X, Ma XQ, Wang R, Johansson S, Wallander MA, et al. Validation of a survey methodology for gastroesophageal reflux disease in China. BMC Gastroenterol 2008;8:37.
Armstrong D, Bennett JR, Blum AL, Dent J, De Dombal FT, Galmiche JP, et al. The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology 1996;111:85-92.
El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: A systematic review. Gut 2014;63:871-80.
Ronkainen J, Aro P, Storskrubb T, Johansson SE, Lind T, Bolling-Sternevald E, et al. Prevalence of Barrett's esophagus in the general population: An endoscopic study. Gastroenterology 2005;129:1825-31.
Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut 2004;53:1730-5.
Zheng Z, Nordenstedt H, Pedersen NL, Lagergren J, Ye W. Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins. Gastroenterology 2007;132:87-95.
Lee SJ, Jung MK, Kim SK, Jang BI, Lee SH, Kim KO, et al. Clinical characteristics of gastroesophageal reflux disease with esophageal injury in Korean: Focusing on risk factors. Korean J Gastroenterol 2011;57:281-7.
Jarosz M, Taraszewska A. Risk factors for gastroesophageal reflux disease: The role of diet. Prz Gastroenterol 2014;9:297-301.
Maity S, Vedasiromoni JR, Ganguly DK. Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis
). J Ethnopharmacol 1995;46:167-74.
Mabe K, Yamada M, Oguni I, Takahashi T.In vitro
and in vivo
activities of tea catechins against Helicobacter pylori
. Antimicrob Agents Chemother 1999;43:1788-91.
Gracioso Jde S, Vilegas W, Hiruma-Lima CA, Souza Brito AR. Effects of tea from Turnera ulmifolia
L. On mouse gastric mucosa support the Turneraceae
as a new source of antiulcerogenic drugs. Biol Pharm Bull 2002;25:487-91.
Vossoughinia H, Salari M, Mokhtari Amirmajdi E, Saadatnia H, Abedini S, Shariati A, et al. An epidemiological study of gastroesophageal reflux disease and related risk factors in urban population of Mashhad, Iran. Iran Red Crescent Med J 2014;16:e15832.
Somi MH, Farhang S, Mirinezhad K, Jazayeri E, Nasseri-Moghaddam S, Moayeri S, et al. Prevalence and precipitating factors of gastroesophageal reflux disease in a young population of Tabriz, Northwest of Iran. Saudi Med J 2006;27:1878-81.
Murao T, Sakurai K, Mihara S, Marubayashi T, Murakami Y, Sasaki Y, et al. Lifestyle change influences on GERD in Japan: A study of participants in a health examination program. Dig Dis Sci 2011;56:2857-64.
Chen T, Lu M, Wang X, Yang Y, Zhang J, Jin L, et al. Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort. BMC Gastroenterol 2012;12:161.
Kumar S, Sharma S, Norboo T, Dolma D, Norboo A, Stobdan T, et al. Population based study to assess prevalence and risk factors of gastroesophageal reflux disease in a high altitude area. Indian J Gastroenterol 2011;30:135-43.
Wendl B, Pfeiffer A, Pehl C, Schmidt T, Kaess H. Effect of decaffeination of coffee or tea on gastro-oesophageal reflux. Aliment Pharmacol Ther 1994;8:283-7.
Falk GW. The possible role of Helicobacter pylori
in GERD. Semin Gastrointest Dis 2001;12:186-95.
Peek RM. Helicobacter pylori
and gastroesophageal reflux disease. Curr Treat Options Gastroenterol 2004;7:59-70.
Beaumont H, Bennink RJ, de Jong J, Boeckxstaens GE. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. Gut 2010;59:441-51.
Kahrilas PJ, Lin S, Chen J, Manka M. The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut 1999;44:476-82.
Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology 2000;118:688-95.
van Herwaarden MA, Samsom M, Smout AJ. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000;119:1439-46.
Isolauri J, Laippala P. Prevalence of symptoms suggestive of gastro-oesophageal reflux disease in an adult population. Ann Med 1995;27:67-70.
Mohammed I, Cherkas LF, Riley SA, Spector TD, Trudgill NJ. Genetic influences in gastro-oesophageal reflux disease: A twin study. Gut 2003;52:1085-9.
El-Serag H. Role of obesity in GORD-related disorders. Gut 2008;57:281-4.
Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, et al. Antiplatelet drugs are a risk factor for esophageal mucosal injury. Digestion 2013;87:281-9.
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]